Invasions of Stomach Tumors in Hypocatalasemic Mice (C3H/Cbs/Gen) Treated with N-Methyl-N-Nitrosourea but Not N-Methyl-N'-Nitro-N-Nitrosoguanidine.

The effect of ubenimex on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumor in rats.

The effect of ubenimex on the progression of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach tumor in rats was studied. Tumor induction was performed by giving MNNG via drinking water for 34 weeks. Ubenimex was ip administered twice a week at 0.5 mg/kg for 84 weeks in one group and 49 weeks in another starting from the first and 36th weeks after initiation of MNNG administration, re...

N-methyl-N'-nitro-N-nitrosoguanidine: reactions of possible significance to biological activity with mammalian cells.

Gibberella fujikuroi mutants obtained with UV radiation and N-methyl-N'-nitro-N-nitrosoguanidine.

N-methyl-N'-nitro-N-nitrosoguanidine (nitrosoguanidine) and to a lesser extent UV radiation are very mutagenic for Gibberella microconidia. The recommended nitrosoguanidine doses lead to much higher frequencies of mutants than are found in other microorganisms. The frequency of mutants among the survivors increases linearly with the nitrosoguanidine dose (molar concentration X time); the absolu...

Ossification of the N-methyl-N'-nitro-N-nitrosoguanidine-induced small intestine adenocarcinomas in rats.

Eighty rats out of 233 developed malignant tumors in the stomach and small intestine by administration of 100 micrograms/ml N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 28 weeks. Fifteen lesions (30%) among the 50 small intestinal carcinomas showed ossification in the tumor, while none in the sarcomas (12 lesions) or gastric adenocarcinomas (59 lesions) showed ossification....

Enhancement of gastric carcinogenesis in dogs given N-methyl-N'-nitro-N-nitrosoguanidine following vagotomy.

In an attempt to improve the method of induction of gastric cancer in dogs, selective vagotomy without drainage procedure was performed before administration of Nmethyl-N †̃-nitmo-N-nitrosoguanidine(MNNG). Twenty dogs were divided into two groups of 10 dogs (five beagles and five mongrels). The control group received MNNG alone. Dogs of the experimental group were vagotomized 2 months before a...